1335. A Translational Nephrotoxicity Model to Probe Acute Kidney Injury with Vancomycin and Piperacillin–Tazobactam

Applying new diagnostic criteria for acute kidney injury to facilitate early identification of nephrotoxicity in vancomycin-treated patients.

Acute kidney injury (AKI) associated with high-dose vancomycin (VAN) therapy is a clinical concern, but no uniform diagnostic criteria exist. The AKI Network (AKIN) proposed new criteria to diagnose AKI based on abrupt changes in serum creatinine or urine output. We conducted a prospective observational study to determine the incidence and severity of AKI and associated outcomes using the AKIN ...

a comparison of teachers and supervisors, with respect to teacher efficacy and reflection

supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...

Comparison of Rates of Acute Kidney Injury with Vancomycin/Piperacillin-Tazobactam vs. Vancomycin/Meropenem Combination Therapy

Vancomycin Trough Levels: Cause or Result of Acute Kidney Injury?

clearance of vancomycin to the clearance of the gold standard glomerular filtration rate (GFR) marker inulin is 0.89 in normal volunteers at steady state with endogenous creatinine as a filtration marker the ratio is 0.79 [5] . Therefore, the vancomycin clearance is a better GFR marker than is the creatinine clearance. Thus the interpretation of trough levels needs to be based on the renal func...

A Microdosimetry model of kidney for nephrotoxicity due to internal radiation therapy

Introduction: We describe a nephron-based dosimetry model for renal toxicity for radiopharmaceutical therapy suited to the nonuniform activity distribution of radiopharmaceutical. In radiopharmaceutical therapy, renal toxicity is observed while whole-kidney and renal cortex absorbed dose values are below toxicity thresholds established by external beam and targeted radiope ptid...